Abstract：Isometric resistance (IR) exercise and whole-body vibration (WBV) exercise have been shown to improve blood pressure and related cardiovascular function indicators. At present, research literature on combining IR exercise with WBV (referred to as isometric resistance vibration, IRV) is insufficient. Therefore, the purpose of this study was to investigate the changes in blood pressure and pulse wave velocity (PWV) following a single bout of IRV. We recruited 17 adult males with inactive and sedentary lifestyles as the participants. They performed IR exercise, WBV, and IRV in a counterbalancing sequence. Each exercise program included a static squat hold (120 degrees of knee flexion). IR exercise was carried out with 30% body-weight, and WBV was performed with body-weight. The vibration frequency and amplitude were set at 30 Hz and 1-3 mm. IRV was combined IR exercise with WBV condition. Blood pressure and finger-toe PWV (ft-PWV) were measured at baseline (rest), postexercise (T0), 15 minutes (T15), 30 minutes (T30), 45 minutes (T45) and 60 minutes (T60) in different courses. The results indicated that IRV resulted in significantly higher systolic blood pressure (SBP) when compared to IR exercise and WBV at T0. However, diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and ft-PWV were only significantly higher than WBV. SBP showed a significant change only between IRV and WBV, while both IR exercise and IRV exhibited significantly greater DBP, HR, and PWV than WBV. We conclude that the reduction of SBP, DBP, HR, and MAP in IRV is more significant than in WBV. These acute changes observed after exercise suggest that IRV appears to exert a greater stimulation on vascular pressure than does WBV. (Full text)